Phosphatidylserine Dosage Guide: How Much Should You Take?
The right Phosphatidylserine dose depends on your experience level, body weight, and what you're optimizing for. Clinical trials have used doses ranging from 100mg to 400mg, with the standard effective range sitting at 100–300mg.
Phosphatidylserine is classified as a phospholipid. It is also known as PS, ptd-Ser. Common goals include memory, neuroprotection, cognitive longevity, stress, athletic recovery.
Phosphatidylserine Dosage by Weight
Phosphatidylserine is not typically dosed by body weight in the clinical literature. The effective dose range is consistent across body weights: 100–300mg for standard use. The calculator above provides personalized ranges based on your experience level and supplement form instead.
How to Take Phosphatidylserine
Timing: Take with a fat-containing meal — PS is fat-soluble and absorption increases with dietary fat. Can be split into 2–3 doses throughout the day (e.g., 100mg three times daily) or taken as one daily dose.
Food: Take Phosphatidylserine with food. Absorption is improved when taken with a meal.
Phosphatidylserine Cycling Protocol
No cycling required. Phosphatidylserine can be taken daily and benefits may be cumulative over months of use. Clinical trials showing significant effects on memory ran for 3–6 months.
Phosphatidylserine Supplement Forms
Soy-derived PS (most researched)Recommended
Soy-derived phosphatidylserine is used in the vast majority of clinical trials including FDA-qualified health claim studies. This is the reference form. Available widely in supplement form.
Sunflower-derived PS (soy-free)
Sunflower-derived PS is a soy-free alternative with similar bioavailability. Use the same dose as soy-derived. Growing evidence suggests equivalent efficacy.
Phosphatidylserine Safety & Side Effects
The maximum recommended dose of Phosphatidylserine is 800mg per day.
Doses up to 800mg/day have been used in Alzheimer's research without serious adverse effects. GI upset is the most common side effect at higher doses. The FDA has granted a qualified health claim for PS and cognitive function (reduced risk of dementia).
Phosphatidylserine FAQ
How much Phosphatidylserine should I take?
The standard dose of Phosphatidylserine is 100–300mg per day. Beginners should start with 100–100mg. Use the calculator above for a personalized dose based on your weight, goals, and supplement form.
What is Phosphatidylserine used for?
Phosphatidylserine is a phospholipid primarily used for memory, neuroprotection, cognitive longevity. Phosphatidylserine is a phospholipid that makes up ~15% of neuronal cell membranes.
Should I cycle Phosphatidylserine?
No cycling required. Phosphatidylserine can be taken daily and benefits may be cumulative over months of use. Clinical trials showing significant effects on memory ran for 3–6 months.